the Kim lab
Our research goal is to investigate how chromatin factors and noncoding RNA transcription control dynamics of RNA polymerase II transcription to coordinate cellular processes upon environmental changes.
Our Lab started in 2013 at Ewha Womans university. Currently, the lab consists of 6 graduate students and 1 undergraduate student.
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Ji Hyun Kim†, Chae Young Yoon†, Yukyung Jun†, Bo Bae Lee, Ji Eun Lee, So Dam Ha, Hyeonju Woo, Ahyoung Choi, Sanghyuk Lee, Woojin Jeong, Ji Hyung Kim, TaeSoo Kim*
NuA3 HAT antagonizes the Rpd3S and Rpd3L HDACs to optimize mRNA and lncRNA expression dynamics
Nucleic Acids Research, gkaa781 (2020)
Histone H4-Specific Deacetylation at Active Coding Regions by Hda1C
Molecules and Cells, In Press (2020)
So Dam Ha#, Seokjin Ham#, Min Young Kim#, Ji Hyun Kim, Insoon Jang, Bo Bae Lee, Min Kyung Lee, Jin-Taek Hwang, Tae-Young Roh*, TaeSoo Kim*
Transcription-dependent targeting of Hda1C to hyperactive genes mediates H4-specific deacetylation in yeast
Nature Communications, 10, 4270 (2019)
Min Young Kim# , Ji Eun Lee# , Lark Kyun Kim* , TaeSoo Kim*
Epigenetic Memory in Gene Regulation and Immune Response.
BMB Reports 52, 127-132(2019)
Rpd3L HDAC links H3K4me3 to transcriptional repression memory.
Nucleic Acids Research, gyk573 (2018)
Determinants of Histone H3K4 Methylation Patterns. Molecular Cell 68(4):773-785 (2017)
Lee BB#, Kim JH#, Kim T
Hyeonju Woo#, So Dam Ha#, Sung Bae Lee, Stephen Buratowski, TaeSoo Kim*
Modulation of gene expression dynamics by co-transcriptional histone methylations
Experimental & Molecular Medicine e326 (2017) # Co-first authors
Ji Hyun Kim#, Bo Bae Lee#, Young Mi Oh, Chenchen Zhu, Lars M. Steinmetz, Yookyeong Lee, Wan Kyu Kim, Sung Bae Lee, Stephen Buratowski*, TaeSoo Kim*
Modulation of mRNA and lncRNA expression dynamics by the Set2-Rpd3S pathway
Nature Communications 7, 13534 (2016)
# Co-first authors
* Co-corresponding authors
TaeSoo Kim, Zhenyu Xu, Sandra Clauder-Münster, Lars M. Steinmetz, Stephen Buratowski
Set3 HDAC mediates the effects of overlapping non-coding transcription on gene induction kinetics
Cell 150, 1158 – 1169 (2012)